Synthesis of Certain Derivatives of Schiffbases of Isoniazid and Its in-Vitro Assay Against Tuberculosis - Multi and Extremely Drug Resistance Strains free essay sample

Microbiological Studies A definitive diagnosis of tuberculosis can only be made my culturing Mycobacterium tuberculosis organisms from a specimen taken from the patient (Most often sputum, but may also include pus, cerebero spinal fluid (CSF)), biopsied tissue, etc. Sputum smears and cultures should be done for acid-fast bacilli. The preferred method for the identification is fluorescence microscopy which is more sensitive than conventional Ziehl- Neelson staining denoted by Steingart et al. , 2006 6. If sputum is not produced, specimens can be obtained by gastric washings, an laryngeal swab, bronchoscopy with broncho alveolar lavage or fine needle aspiration of a collection. A comparative study found that inducing three sputum samples is more sensitive than three gastric washings. Many types of culture media are available. Traditionally Lowenstein –Jensen (LJ), Kirchner or Middle Brook media (7H9, 7H10, 7H11 and 7H12) are used for cultivating of Mycobacterial species. A culture of the acid-fast bacilli distinguishes the various forms of Mycobacteria. We will write a custom essay sample on Synthesis of Certain Derivatives of Schiffbases of Isoniazid and Its in-Vitro Assay Against Tuberculosis Multi and Extremely Drug Resistance Strains or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page New automated systems that are faster include BACTEC 460 TB, BACTEC 9000 and the Mycobacterial growth Indicator tube (MGIT). The microscopic observation drug susceptibility assay (MODS) culture may be faster and more accurate method. Drugs Used In Tuberculosis in the current scenario Active tuberculosis will kill about two of every three people affected if left untreated. Treated tuberculosis if taken up early has a mortality rate of less than 5%. The standard short course treatment for tuberculosis comprises of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol for two months, then Isoniazid and Rifampicin alone for a further four months. For latent tuberculosis, the standard treatment is six to nine months of Isoniazid alone. Drug regimens are abbreviated in a standardized manner. a). Streptomycin is STM or S b) Isoniazid is INH or H c) Rifampicin is RMP or R d) Ethambutol is EMB or E e) Pyrazinamide is PZA or Z. a)According to WHO norms, there are six classes of second line drugs that are used for the treatment of tuberculosis. A drug may be classified as second line instead of first line for one of two possible reasons; it may be less effective than the first line drugs or it may produce toxic side –effects. They are classified based on their chemical nucleus: Aminoglycosides – Amikacin and Kanamycin b)Polypeptides – Capreomycin c)Fluoroquinolones – Ciprofloxacin d)Thioamides – Ethionamide, Prothionamide and Cycloserine. e)Para-amino Salicylic acid. Tuberculosis has been treated by combination therapy over fifty years. Single drug treatment is ineffective and regimens that use only single drugs result in the rapid development of resistance and thus treatment results in failure. The rationale for using multiple drugs to treat tuberculosis is based on simple probability. The frequency of spontaneous mutations that confer resistance to an individual drug is well known: 1 in 10 7 for Ethambutol (EMB); 1 in 108 for streptomycin (STM) and Isoniazid (INH); 1 in 10 10 for Rifampicin (RMP). A patient with extensive pulmonary tuberculosis has approximately 10 12 bacteria in his body and therefore will probably be harbouring approximately 10 5 Ethambutol resistant bacteria, 10 4 Streptomycin resistant bacteria, 104 Isoniazid resistant bacteria and 102 Rifampicin resistant bacteria respectively. DOTS stands for ‘Directly Observed Therapy, Short course’ and is a major plank in the WHO global tuberculosis eradication programme. The WHO advises that all tuberculosis patients should have atleast the first two months of their drug therapy should be observed with the aid of observer within that society. DOTS is used with intermittent dosing – Thrice weekly (Rifampicin, Isoniazid, Ethambutol and Pyrazinamide) or twice weekly. The relative incidence of major adverse effects has been carefully described . a)Isoniazid – Hepatitis, Neuropathy – 0. 49%. )Rifampicin – Skin rash, Thrombocytopenia and Hepatitis – 0. 43 % c)Pyrazinamide – Skin rash and Hepatitis 1. 48 % d)Streptomycin – Vertigo 0. 43 % Drug Resistant Tuberculosis (MDR and XDR – TB) Multi Drug Resistant Tuberculosis (MDR-TB) is defined as tuberculosis that is resistant at least to Isoniazid and Rifampicin isolates. In the year 2006 â€Å"Extensively- Dr ug Resistant Tuberculosis† (XDR-TB) has emerged and defined as multi drug resistant tuberculosis that is resistant to quinolones and also to any one of kanamycin, capreomycin or amikacin. A 1997 survey of 35 countries found that 2% of the tuberculosis populations are infected by drug – resistant tuberculosis. The highest rates were in USSR, The Baltic states, Argentina, India and China. In 2006, MDR –TB in New York city has been increased to 20-30%. Annual risk of mortality rates increases by 10-15%. There is currently an epidemic of XDR-TB in South Africa. The outbreak was first reported as a cluster of 53 patients in a rural hospital in Kwazulu –Natal of whom 52 died . The treatment and prognosis of MDR-TB are much more akin to that of cancer than to that for infection. In these aspects, molecular manipulation is a productive source of new drugs. This research work pertains to the modification of Schiff bases on isoniazid to explore the new drugs with a desire to obtain highly potent, more specific and less toxic drugs. In the foregoing literature retrieval, it had been observed that the drug design can be performed by molecular manipulation and resulting in new productive drugs. The biological study of natural products with medicinally useful property and some of the chemical structure and its analogs had furnished to lead compounds, and its variation in the biological behavior. The pre-existing tuberculosis had made a challenging effect of medicinal chemists resulting in the extreme drug resistance. The performance of molecular manipulation still existed in a major line approach for the discovery of new drug analogues. To synthesize a derivative, an intermediate step has to be performed and to proceed for the further molecular manipulation. Combination of two or more active moieties in to one is a common procedure of manipulation and this can be possibly result in augmenting the activity, removal of untoward side effects and particularly to prevent development of resistance by the infectious microorganisms. Abundant literature support were available with regard to the study of Schiff bases as potent antibacterial, antifungal, antihypertensive, antiviral and anticancer perspectives. Schiff bases were the intermediate for the synthesis of azetidine -2 4- ones, thiazolidine -2 4- ones, triazoles tetrazoles. It was interesting to observe that some analogues of Schiff bases were combined with other moieties like phenothiazines,hydrazines and some hydrazide derivatives of carboxylic acid resulting in a better performance in their respective biological activities. Hence, it was our interest to associate the Schiff bases with the primary drug isoniazid. Since Isoniazid is a well known antitubercular drug. As a vast number of reports were been available regarding the antitubercular perspectives of the isoniazid, there is still lacuna existing in the study of Schiff bases in the multi drug and extremely drug resistant M. tb strains. This study will full fill the properties of Schiff bases relevant to the prevailing drug resistant tuberculosis. Biological activities of Schiff bases Schiff bases are of interest and its important moiety which is associated with biological activity. Initially, most of the research program has been conducted to explore the antimicrobial perspectives of Schiff base derivatives. Based on the intermediate Schiff base various molecular manipulation were attempted to investigate and discover an effective antibacterials, antifungals antiviral agents. In this preview of literature the various activities of Schiff bases pertaining to antibacterial perspectives has been studied. 1. Hearn et. al. , 2003 7 performed enzymatic acylation of the antitubercular isoniazid (INH) by N-acetyl transferases reduces therapeutic effectiveness of the drug. Since it dealt with the major metabolic pathway for INH in human beings, many of these derivatives were prepared and screened against Mycobacterium tuberculosis in the mice. They conclude the structural cogners of metabolites of INH may serve as significant leads in antitubercular drug discovery and in the exploration of the mode of action of INH. 2. Tarek Aboul fadi et. al. , 2003 8 had synthesized N- alkyl derivative of INH and the Pharmacokinetic studies were been carried out in the bovine and sensitive strains of Mycobacterium tuberculosis. The pharmacokinetic study revealed that the rate and extent absorption of the tested derivatives. They show relative bioavailability of 183. 15 and 443. 25 respectively. 3. Sultana et. al. , 2007 9 studied the synthesis of hydrazones. The study afforded to the hitherto unreported 1-(4-chloro benzylidene) – hydrazinophthalazine, 1- nitrobenzylidene hydrazine phthalazine. , 3-(4-Chlorophenyl) –S-Triazolo (3,4-a) phthalazine. These structures were confirmed by spectroscopic techniques – IR, UV, H-NMR, EIMS, FD HRMS. Anti hypertensive activity were been evaluated. 4. Koussi and Abdel rahman. , 2006 10 illustrated certain novel Schiff bases of 4- methyl-1,2,4 –triazole -3-mercaptoacetic acid hydrazide were synthesized and their chemical identities were elucidated by elemental analyses. IR, H-NMR,13- C-NMR and mass spectral data. The percentage of the geometrical isomers was elucidated using the 1-H NMR. The synthesized compounds were selected for screening at the tuberculosis antimicrobial acquisition and co-ordination facility against Mycobacterium tuberculosis H37RV strain in which they showed moderate activity at a concentration of 625 mg/mL. . Jiang et. al. , 2003 11 studied the series of chemically modified aryl- aldehyde Schiff bases has been synthesized and tested for their antioxidant activity and radiation protection. It was observed that disulfide –containing aryl –aldehyde schiff base exhibited potent free radical scavenging, antioxidation and radioprotective activities. 6. Pandeya et. al. ,1999 12 synthesized antib acterial, antifungal and anti human immunodeficiency virus activities of Schiff and Mannich bases derived from isatin derivatives and N – (4-(4’ chlorophenyl) thiazolyl thiosemi carbazide. Investigation of antimicrobial activity of compounds was done by agar dilution method. 7. Jayasekar et. al. , 1997 13 synthesized the Schiff bases of mesalazine and studied the anti inflammatory activity. The inhibition shows about 50-60% of the potency of the drug. In the present study, we had investigated certain Schiff base derivatives modified from isoniazid and it has screened for Extreme drug-resistant and Multidrug resistant tuberculosis strain procured from the patients suffering from tuberculosis. Bibilography: 1. Rothschild, B. , Martin, L. , Bercovier, L. G. , Gal, B. G. , Blatt, G. C. , Donoghue, H. , Spigelman, M and Brittain, D. Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present. Clin. Infect. Dis. 30(3) : 305-311 ( 2001). 2. Pearce-Duvet, J. The origin of human pathogens evaluating the role of agriculture and domestic animals in the evolution of human disease. Biol. Rev. Camb. Philos. Soc. 31(3) : 369-382 (2006). 3. Koch, R. Die Aetiolgieder Tuberculosis. Berliner Klinsche Wochenschrift. 19 : 221-230 (1882). 4. Wells, A. Q. The Murine type of tubercle bacillus : Medical Research Council Special Report No. 259. HMSO, London (1946). 5. Mark Spigelman, 2008. Excavated Jericho Bones may help Israeli- Plaestinian – German team to combat tuberculosis. News release, Feb 29, (2008): 1-5. 6. Steingart,K. , Henry,M. , Pasval,G. , Avery,T. O and Lyall, W. H. Fluorescence versus conventional sputum smear microscopy for tuberculosis : a systematic review. Lancet. Infect. Dis. 6 : 570-571 (2006). 7. Michael J Hearn, Michael H Cynamon. Design and synthesis of antituberculars: preparation and evaluation against Mycobacterium tuberculosis of an isoniazid Schiff base. Journal of Anti Microb. Chemotherapy. 53(2):185-191 (2004). . Tarek Aboul-Fadl, Faragany Abdel-Hamid Mohammed, Ehsan Abdel-Saboor Hassan. Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH). ARCHIVES OF PHARMACAL RESEARCH , 26(10):778-784 ( 2003 ). 9. Sultana-N; Sarfaraz-TB; Nelofar-A; Hussain-SA. Potential antibacterial agents: Part VI Syn thesis and structure elucidation of schiff bases derived from hydralazine. Pak-J-Sci-Ind-Resch (Pakistan-Journal-of-Scientific-and-Industrial-Research); 50(3); 169-172 (2007). 10. El-Koussi-NA; Abdel-Rahman-HM . Novel 1,2,4-triazole-3-mercaptoacetic acid derivatives as potential antimycobacterial and antimicrobial agents. Bull-Pharm-Sci-Assiut-Univ (Bulletin-of-Pharmaceutical-Sciences); 29(Part 1); 127-136 (2006). 11. Jiang-JJ; Chang-TC; Hsu-WF; Hwang-JM; Hsu-LY. Synthesis and biological activity of sulfur-containing aryl-aldehyde Schiff bases. Chem-Pharm-Bull (Chemical-and-Pharmaceutical-Bulletin); 51(11); 1307-1310 (2003). 12. Pandeya-SN; Sriram-D; Nath-G; De-Clercq-E. Synthesis, antibacterial, antifungal and anti HIV activity of Schiff and Mannich bases of isatin with N-(6-chlorobenzothiazol-2-yl) thiosemicarbazide. Indian-J-Pharm-Sci (Indian-Journal-of-Pharmaceutical-Sciences); 61(6); 358-361 (1999). 13. Jayasekhar-P; Rao-SB; Santhakumari-G. Synthesis and anti-inflammatory activity of Schiff bases of mesalazine. Indian-J-Pharm-Sci (Indian-Journal-of-Pharmaceutical-Sciences); 59(1); 8-12 (1997). 14. Mcomia ; Protective group in Organic chemistry. P-66. 15. Trivedi,P. , Undavia,N. K. ,Dave, A. M. , Bhatt,K. N and Desai ,N. C. Indian Journal of Chem . , Vol 32B(7) : 760-765 ( 1993). 16. Divakar, C. M and Nair, G. R. N. Antiulcer, antibacterial and spermicidal activities of Salanin. Indian Drugs. 38(2): 629-932 (2001).

Italian Words Beginning With the Letter Z

Italian Words Beginning With the Letter Z Try out these Italian words beginning with the letter Z, with their English translations: zacchera – splash of mudzaccherone  Ã¢â‚¬â€œ mud-bespattered personzaffare – to stop upzaffata – stenchzafferano – saffronzaffirino – sapphirezagara – orange blossomzaino – knapsackzampa – leg, footzampare – to paw the groundzampillante – gushing, spurtingzampirone – fumigatorzampogna – bagpipezana – basketzangolare – to churnzanna – fang, tuskzanni – clown mask, fool, zanyzanzara – mosquitozappa – hoezappare – to hoezattera – raft, slabzavorro – ballast, dead weightzazzera – mop of hairzecca – mintzecchino – sequinzelante – zealouszelo – zealzenit – zenithzenzero – gingerzeppa – wedgezeppo – packed, crammed, burstingzibaldone – mixture, medleyzelo – zealzerbino – matzibellino – sablezimbellare – to lure, to enticezimbello – decoyzinc are – to coat with zinczinco – zinczio – unclezippolo – pin, pegzitto – silencezizzania – discordzocollaio – clog makerzocollare – to clatter about in clogszodiaco – zodiaczolfo – sulfurzolla – clodzollette – sugar cubezompare – to jump, to leapzona – zone, bandzoologia – zoologyzoppaggine – lameness, shake, ricketyzoppicare – to limpzoticaggine – roughness, boorishnesszoticone – boor, lout, rough personzucca – summer squashzucchero – sugarzuccheroso – sweet, sugaryzucchino – squashzuccone – blockheadzuffa – scuffle, frayzufolare – to whistlezuppa – soupzuppiera – soup tureenzuppo – soaked

A Description of the Attributes a Presidential Candidate Should Have Essay Example for Free

A Description of the Attributes a Presidential Candidate Should Have Essay ? The American President represents much more than an institution. To people around the world he is representative of their hopes and fears for the future and is the focus of intense feelings and emotions. The voting process represents an extremely significant period in American politics where US citizens vote for their President. Their votes are reflective not only of the candidate they like and respect the most, but are also an indication of the person that they predict will be the most effective once in office. Despite this, their decisions are based on the candidate’s performance prior to, and during, the election process. This performance that may not necessarily be a good indication of their actual ability to run the country; the qualities needed to become a President are very different from those required to be a successful President once in office. This paper will address the attributes that are commonly cited as being necessary for someone to become a President and will dispute a number of these, offering the opinion that they are not necessarily the correct basis on which judgments should be made. The skills and methods by which an elective may become a President are explored and will be compared to those that are actually required and valued once in office. In the United States the absence of a monarchy entails that the President often becomes the object for nationalistic or monarchical type sentiments that people in countries like England would direct at their Queen. The President is undoubtedly the most important figure in the US and holds several roles including Chief Executive, Commander in Chief, Head of the National Party and Chief Legislator. However, like the Queen in England, his supreme court have opposing powers to him and thus limit his ability to carry out some of his roles. Many people recognize one of the most important attributes for a Presidential candidate to be is a good, strong decision maker with a clear vision and direction. Candidates often use the election process to discuss problems that are evident in the way in which the country is currently being run and make willful claims as to how they would do things differently. They swear that they will have the backbone to take decisions that Presidents before them have failed to take. These type of statements appeal to the American public as they provide hope for a better future and an expectation that things will change for the better. The truth, however, is very different. Congressmen have their own electorate, interest groups and opinions on how the country should be run. The President is actually very limited in his ability to command congress to do anything and thus, the implementation of his decisions is actually a very difficult thing to achieve. What is, perhaps, more important than an ability to make decisions is an ability to persuade and influence others. If you ask people if they would vote for someone who uses strong powers of persuasion to sway their vote they would probably say no, they would prefer to vote for some who have a strong direction and vision. They wouldn’t like to feel that clever vocabulary or some type of sales approach has influenced them. No, they prefer to consider themselves people who have made a good decision based on the facts. The truth, however, that they probably were persuaded and swayed during part of the election process. This is not such a bad thing. The ability to persuade others is crucial to a successful President as he needs to be capable, through whatever means necessary, to convince others to carry out the decisions he makes. It is therefore clear that, whilst a clear vision and direction is important, what is more important both in gaining the role and completing it successfully is an ability to persuade and influence. The person who manages to influence others will do the better job, once in power it will help him get things done and in becoming President it will help him win. A further attribute that the American public will look for when selecting a Presidential candidate is a consistency of purpose. People want a President who will have courage to commit to their course of action and achieve the plans they lay out during the electoral process. However, again this may not be an attribute that delivers success once a candidate is in power and we often see very different expectations of the President. President George Bush can be cited as a prime example of this. George Bush was clear and strong in his plan to rid Iraq of Saddam Hussain, so much so that he took the United States to war. However, he later faced a great deal of criticism for his actions and many camps argue that he should have admitted he was wrong and should withdraw US troops from the US. His commitment to action was no longer valued. This paper is not intended to debate this point and pass judgment on George Bush’s actions but is using this example to show that the attributes that people may look for when selecting a President; consistency and relentless purpose may not always be what they expect once they are in power. An attribute that features heavily in people’s decision when selecting a President is realism, they like a family man whose values and emotions may seem to reflect their own. They want to feel that their President, as much as possible, has the same feelings and fears that they do and will thus act in a way that is in their interests. Whether appropriate or not, the past and present personal life of a Presidential candidate features heavily during the election process and people look for someone who has lived their life in a good and true manner. Whilst such attributes provide an indication of a person’s character and may be seen to represent the way in which they will behave once they are in power, they are not necessarily what people look for once their President are in power. They are more concerned with a person’s ability to cut themselves off emotionally from any decisions they make, distancing themselves from a situation in order to look at a bigger picture. The phrase â€Å"don’t mix business with pleasure† could not be more appropriate for a President in power. Once in the Whitehouse people consider the figurehead to be an American institution; he works for them. Personal life is no longer to be considered to be of relevance and, in many respects; they do not wish a President to show feelings as these can be construed as a weakness. Other commonly cited attributes that people discuss when they are asked what they look for in a President include honesty, integrity, leadership and intelligence. These types of attributes entail that the opinions people form of candidates prior to their election, and thus the benchmark against which they are judged once they are elected, can never be met; they are all extremely subjective values. A candidate who is elected as a new President, a replacement for the incumbent, will always be heralded as the next big thing. The nation will feel strong hope for the future of America and will truly believe that things will change for the better. However, the likelihood is that these expectations can never really be met. Time will change the position that the President occupies in people’s minds; what people perceive as good leadership now will almost certainly change over the course of the four years between elections. As such, these attributes cannot accurately be used as representations of how well a candidate will perform once in office. This paper has addressed a number of the common attributes that people cite as important within a Presidential candidate. Through exploring the difference between winning an election and actually running a country, the flawed nature of the factors upon which many votes are cast is revealed. Whilst people recognize they are voting for someone who will run their country, they rarely seem to consider the attributes that will be valued in this role, instead focusing on those required to get there. Fighting a Presidential campaign is very different from being a President. Along these lines more emphasis should be placed on attributes such as attention to military threats and needs, the economy and American interests, both at home and abroad. A Description of the Attributes a Presidential Candidate Should Have. (2016, Nov 01).

Achieving Community Awareness and Commitment Coursework

Achieving Community Awareness and Commitment - Coursework Example In this regard, the leaders are required to increase efficiency along with quality of different sustainable community activities (Bagin et al., 2012). Based on the current policy statements and communication formats, the proposed coursework tends to focus on discussing about the operationalized practices of the educational system of Rome City School District (RCSD), New York based on two major parts. The first part of the discussion incorporates the provisions of providing report card information of the school to a heterogeneous group of community members. In this regard, the discussion analyses the report card information by considering major areas of the school and possible questions that might be occurred relating to the current report cards and communication formats of the institution. The second part of the proposed coursework identifies and evaluates activities to be performed in the assessment that can help RCSD to accomplish its marketing and promotional goals of different academic courses successfully. According to the communication formats of the current educational system in the US, there are a number of guiding principles and policies duly accepted by the regulatory departments in order to increase efficiency of the reporting functions. In this regard, the report card information format of RCSD includes a clear structure of presenting the current educational procedures of the schools with adequate standards, which can be interpreted easily by a heterogeneous group of the community members (Bagin et al., 2012). In order to assess critically the key areas in the current report card information format of the institution, the following three key areas are considered that can differentiate the roles and significance of the RCSD to communicate to the existing community members efficiently. According to an in-depth understanding of the current report card format, compliance with the standards can be considered as a major key aspect that enable RCSD to

Servant Evangelism Report Personal Statement Example | Topics and Well Written Essays - 750 words

Servant Evangelism Report - Personal Statement Example   The opportunity to assist the victims developed when I heard of the catastrophe that hit the Hurricane victims in some parts of the United States. The catastrophe left many people homeless and hopeless in life. I was able to share the gospel and my testimonies of life tribulation with the hurricane victims. Most of the victims were of the opinion that, God works in various ways, in relation to my testimonies. According to James 2:14-20, there is certainly no act of goodness when a Christian fails to assist an individual physically. Most of the victims ended up accepting Jesus Christ as their personal savior. Consequently, faith without works is as impeachable as dead. The hurricane victims lost a lot, and all they needed was some form of comfort in someone to talk to about their loss.   Physical Assistance   I managed to raise some money and bought a few blankets, clothes and some food that I donated to the victims. I felt the need to express faith in action by comforting the mourners. However, the mourners felt that someone still cared for them even after the worst experience. I explained to them that God worked in the same way, despite what they are going through God is still with them, and is using the experience as a test their faith. I encouraged them never to lose faith in Him and that this was their chance to give their lives to Christ. Most of them were for the idea of accepting Christ as their personal savior, and I consider my evangelism a success.

Enlightenment Essay Example for Free

Enlightenment Essay Immanuel Kant In December 1783 Johann Friedrich Zà ¶llner published an article in Berlinische Monatsschrift that stated his opposition to civil marriage, an idea proposed in a previous issue of the journal. Zà ¶llner wrote that the foundations of morality had been shaken in the name of enlightenment and concluded his piece with the question â€Å"what is enlightenment?† Zà ¶llner asserted that this question must first be answered before â€Å"one begins to enlighten†[1]. Immanuel Kant’s reply to Zà ¶llner’s question is often considered the most famous and most important. In his essay, Kant succinctly outlined his opinion on what enlightenment is, the obstacles to enlightenment and how individuals achieve enlightenment. Kant defined enlightenment as â€Å" man’s release from his self-incurred tutelage† and the â€Å"courage to use your own reason[2]†. Kant believed that â€Å"laziness and cowardice† were the prime reasons why many men remained un-enlightened[3]. Kant asserted that people refused to throw off the yoke of â€Å"self-imposed tutelage† because it was easier to pay people to think for them and run their lives[4]. As Kant put it a person could pay to buy a book to serve as understanding, a pastor to serve as a conscience and a physician to determine a diet. There was no real need for an individual to exert their own will or their own reason since these â€Å"benevolent guardians† would take over an individual’s life for them[5]. The act of enlightenment, therefore, was the act of rejecting this easy form of life and asserting the primacy of your individual reason to reject the conventions of the social guardians who Kant asserted herded soc iety like docile, dumb livestock[6]. It is necessary to understand Kant’s definition of enlightenment in order to gain some understanding of what Kant thought was an enlightened age and what was an age of enlightenment. Kant argued that obstacles to individual enlightenment went beyond self-imposed obstacles. Freedom was the essential ingredient for enlightenment. Society, however, imposed restrictions on freedom through laws and religion that constrained free thought through law, convention or threat. Knowledge was also a requirement but access to it was often very restricted and guarded in late eighteenth century Europe but attempts were being made to bring knowledge to the masses. An age of enlightenment was a time when obstacles to enlightenment were being removed or eroded, Kant believed that late eighteenth century Europe was in such an age. As a society allowed more freedom, it became more enlightened. An enlightened age, therefore, was an age when obstacles had been removed and individuals and society wer e enlightened and free to pursue self determination and self rationalization[7]. Kant did not try to assert that the only path to freedom lay on the path of revolution. Revolutions, according to Kant, merely replaced â€Å"old prejudices† with â€Å"new prejudices†[8]. Kant acknowledged that for a society to function properly, for a government to help its people, it was often necessary for an individual to â€Å"narrowly restrict† their reason in the pursuit of their job or duties. Kant defined this as private reason and deemed it a necessity. Kant used an example of how disastrous it would be for an office to question the appropriateness of an order rather than obeying it[9]. The private use of reason was offset by an individual’s public use of reason. In this form of reason the individual takes upon the mantle of a scholar who â€Å"has complete freedom, indeed even the calling, to impart to the public all of his carefully considered and well-intentioned thoughts†[10]. Private reason would compel an individual to pay a tax, pu blic reason would compel the individual to speak out against the necessity of the tax. These two forms of reason allow a society as a whole to move towards enlightenment on the thoughts of enlightened individuals who are active members of society serving as agents of change but not necessarily revolution. As a society becomes more enlightened, individuals are freer to act upon the enlightened opinions reached through their public role as a scholar. This is a gradual process and Kant’s defense of the necessity of private reason implies that a disobedient society itself is an obstacle to enlightenment[11]. The strength of Kant’s arguments lay in the context of when and where he wrote them. Kant lived in a monarchical society that allowed for little individual freedom or representation. Kant’s evolutionary nature of enlightenment worked well in a society that is essentially not free. History proved that societies that gradually allowed more and more freedom were able to maintain stability and encourage at least a small group of scholars to try to lead society’s trip to enlightenment. A steadily evolution towards enlightenment will work in a society that is more restrictive or less representative of the people because the slow rate of changes will still be perceived as changes and many will be patient with a slow but steadily progression of change. In a more representative form of government, however, revolutions are built into the government through elections. If the elected leaders do not implement the ideas of those who elected them, the people become dissatisfied and disobedient. So obstacles to enlightenment can be increased. However, such systems by nature are built to accept and expect a fairly rapid pace of change that would not be possible in a monarchy. New ideas can be implemented nearly every election so in this regard revolution, which in this regard are elections. If quick change is not implemented then the people grow frustrated and disobedient. The dynamic is more complex than in a monarchy. Freedom of thought is all that is required for individual enlightenment. Even the most repressive regimes find it impossible to block an individual from thinking. So to some degree Kant doesn’t allow for enlightenment to happen in the absence of freedom. The freedom to think and act upon those thoughts is the definition of Kant’s public reason. But Kant’s definition of private reason seems incomplete. While it is necessary for an individual to restrict their opinions based on duty or situation, that act does not restrict individual enlightenment. The full scope of what Kant described as a public scholar is the freedom to think and give voice to those thoughts, a private reason may also exist that allows an individual to think but not be able to give voice to such thoughts. This is different from sublimating their opinions to perform a duty. This is done perhaps more out of fear than a sense of duty. A soldier may not be free to question an order but in a more repressive society an enlightened individual may not be free to give voice to their opinions without penalty of death. In such a case is an individual a coward or lazy? Certainly it takes a high degree of courage to speak out but to call those not willing to die for their opinions but how are self realized enough to have those opinions cowards is not just nor fair. In a way Kant both argues against revolution but calls those unwilling to rebel in restrictive cases cowards. So he undercuts his own argument if it’s taken out of the context in which he wrote it where thought was tolerated as was the scholarly debate of enlightened ideas. Immanuel Kant’s essay â€Å"What is Enlightenment?† is justly considered an important work regarding the enlightenment and reason. Kant concisely argues his opinion and presented examples to illustrate his points. The arguments made are strong and logical in the context of the monarchal society Kant lived in that while restrictive, allowed for some freedom of thought and expression. Kant’s arguments lose some strength when applied to different societies and governments. †¨Sources Kant, Immanuel. What is Enlightenment? September 30, 1784. Naragon, Steve. Johann Friedrich Zà ¶llner. Manchester College. 23 June 2011. http://www.manchester.edu/kant/bio/FullBio/ZollnerJF.html.

Benjamin Franklin :: essays research papers

Benjamin Franklin believed that by watching and studying one’s own behavior, that person would be able to improve themselves by knowing their like and dislikes, wants and needs, etc. I agree with Franklin’s theory and think that this is one of the few things in life that a person has control over in order to change their overall being. For the best or worst knowing yourself makes it easier to decide things for yourself and gets a person to become, in a way, one with themselves. Analyzing one’s own behavior is very beneficial if the person is strong or willing enough to not only realize their good qualities but also recognize the bad things about themselves. By studying your behavior you can find things that make up your character and, individually change or eliminate those factors so that you’re a better person. If a person is mentally weak, the recognizing of their bad traits may discourage them or cause a downfall in some aspect of their lives. You would be able to focus more on how you want to be and work towards that goal b y â€Å"adding or subtracting† good traits for bad ones.   Ã‚  Ã‚  Ã‚  Ã‚  Working towards your goal would be fulfilling in that you’re working towards a physical and/or mental mindset of how you want to be. Of course, no one would have the same goal. One person’s goal may sound like another’s but our differing characters and ways of examining life will make them different and unique. In my own experience, examining my behavior helped me to begin exercising. Before I started to exercise, I had a lot of extra time on my hands and felt that I wasn’t where I wanted to be physically because of noticing that I wasn’t able to run as fast as I once could. After realizing this, I began to exercise and, enjoyed it to the point where after my running time returned I continued to work out. I felt good about myself and how exercising is a part of my schedule. I found out what I needed to fill the gap in my life through self-examination.   Ã‚  Ã‚  Ã‚  Ã‚  Although self-improvement by self-examination, in my opinion is good, there are limits. No human being is perfect! If you try to become perfect, you will fail. We all have our own faults and they may or may not exist all the time. No matter what, we always commits faults, even if we don’t act them out, thinking them is just as bad. Benjamin Franklin :: essays research papers Benjamin Franklin believed that by watching and studying one’s own behavior, that person would be able to improve themselves by knowing their like and dislikes, wants and needs, etc. I agree with Franklin’s theory and think that this is one of the few things in life that a person has control over in order to change their overall being. For the best or worst knowing yourself makes it easier to decide things for yourself and gets a person to become, in a way, one with themselves. Analyzing one’s own behavior is very beneficial if the person is strong or willing enough to not only realize their good qualities but also recognize the bad things about themselves. By studying your behavior you can find things that make up your character and, individually change or eliminate those factors so that you’re a better person. If a person is mentally weak, the recognizing of their bad traits may discourage them or cause a downfall in some aspect of their lives. You would be able to focus more on how you want to be and work towards that goal b y â€Å"adding or subtracting† good traits for bad ones.   Ã‚  Ã‚  Ã‚  Ã‚  Working towards your goal would be fulfilling in that you’re working towards a physical and/or mental mindset of how you want to be. Of course, no one would have the same goal. One person’s goal may sound like another’s but our differing characters and ways of examining life will make them different and unique. In my own experience, examining my behavior helped me to begin exercising. Before I started to exercise, I had a lot of extra time on my hands and felt that I wasn’t where I wanted to be physically because of noticing that I wasn’t able to run as fast as I once could. After realizing this, I began to exercise and, enjoyed it to the point where after my running time returned I continued to work out. I felt good about myself and how exercising is a part of my schedule. I found out what I needed to fill the gap in my life through self-examination.   Ã‚  Ã‚  Ã‚  Ã‚  Although self-improvement by self-examination, in my opinion is good, there are limits. No human being is perfect! If you try to become perfect, you will fail. We all have our own faults and they may or may not exist all the time. No matter what, we always commits faults, even if we don’t act them out, thinking them is just as bad.

Leadership Versus Management Essay

Introduction: Management versus Leadership Leadership can take on many meanings, be viewed in many different ways and is often misconstrued with management. To understand leadership and management a clear definition has to exist and the person(s) involved in leading or managing must have clear insight of what expectations are required to reach a specific goal. Therefore, this research paper as identified by this author will define leadership and management as they are defined in the Webster’s Dictionary and other scholarly approved references. In addition, this paper will state a personal philosophy of eadership and management and will unpack and explain the language used in each definition. Second, this paper will identify success in leadership for becoming a great leader, and then compare and contrast leadership and management. Finally, the conclusion will summarize the entire paper by stating what is essentially more important, leadership or management. A Personal Philosophy of Leadership In order to understand leadership, the definition ofa leader must be stated. As indicated in the dictionary, â€Å"a leader is someone who leads, is in front or who takes charge. The word lead means to guide† (The Merriam Webster Dictionary, 2004). As stated by an author, â€Å"Leaders take the lead. That is, they initiate ideas and plans. Leaders move people to follow them by showing them consideration! † (Ford 1991 , 25) This author understands a leader to be one who influences and encourages another to follow in doing something great. This author defines leadership as â€Å"the process of, through the power and direction of God, learning how to build relationships with others, allowing them an opportunity to expound on different ideas and thoughts, growing together in knowledge and working together in harmony to accomplish a mutual goal† (Sharp 2007). Leadership is the ability to be responsible, ethical, and have impeccable moral qualities. It is not Just being responsible, ethical, and moral while working within or on a Job, but it is maintaining that standard and continuing to live that lifestyle at all times. It is not the leader saying â€Å"do what I say, but not as I do. Rather, it is dedicating life to God allowing Him to enhance the character required for being that great leader. An extremely profound definition of Christian Leadership was stated this way: â€Å"Christian leadership is a relationship based on God’s Love which is imitated by the participants, the leader(s) and follower(s). T hey both work together in a mutual, accountable, dynamic relationship of duel influence with one another and the whole of the organization, for the purpose of accomplishing shared, God given, visions, purposes and goals† (Sharp 2007). This definitions center is the love of God. As understood by this author, the love flows through both the leader(s) and follower(s). This love will allow both the ability to work together creating a powerful relationship whereby both will not only be able to influence each other, but will be able to influence others as well, until ultimately they ave completed and accomplish that mutual goal. Another author defined leadership this way: â€Å"Christian leadership is a dynamic relational process in which people, under the influence of the Holy Spirit, partner to achieve a common goal – it is serving others by leading and leading others by serving

Problems Encountered Essay

It should be noted that flaws in every activity held within the organizations capacity is inevitable. As an organization covered and recognized under the jurisdiction of LNU, the Association of Political Science Students is expected to conduct and deliver activities consistent with that of the University or in consonance with its own personal interest. Provided however, that it will not disrupt the principles from which this University was founded. As the organization directs its activities, several problems erupted which hindered the same to deliver what is known as â€Å"best†. Problems in Performance, Preparation, Consistency and Criticisms existed. Problems encountered: 1) Performance Lack of cooperation and incompetence were encountered. For instance, annually, the Leyte Normal University as a whole celebrates its Founding Anniversary. The APSS, as an organization of, and in line with the celebration of the latter, conducted an exhibit labeled â€Å"Political Jungle†. During the conduct of the same, the APSS failed to deliver (although not entirely) what was being portrayed in the exhibit which resulted to criticisms not only by students but the Deans and teachers as well. With realization of failure, the APSS, specifically the committees involved felt drastic loss, low-morale and degraded at some point. 2) Preparation Lack of participation and readiness were encountered. To be more specific, the problems were encountered during when the APSS conducted a Lecture-Forum regarding the controversy on the West Philippine Sea (South China Sea). During the preparation of said event, the organizers due to lack of authority, if not, laziness failed to foster participation and cooperation amongst the Political Science Students needed in order to better realize the success of the event. With that occurrence, the organizers (committees) involved had trouble with all aspect in the preparation of the event, that is to say, the over-all appearance of the venue, logistics, etc. 3) Consistency and Criticisms Problem in the conformity of thoughts was encountered. It is common in every organization to argue on what concept to use whenever the latter conducts its activities provided that conformity is achieved. However, during the last activity held by the organization, that is, an exhibit entitled â€Å"Political Jungle†, the concept used was concluded by the majority of First year students independent of the higher years. Which eventually resulted to perplexity on the part of the former considering the fact that, the concept used to aid the event was poorly conceptualized – â€Å"The Naked Jungle of the Political Animals†. It left the activity and the APSS itself vulnerable to criticisms and confusion on the part of the individuals visiting the exhibit- – and it did.

Laos Facts, History, and More

Laos Facts, History, and More Capital: Vientiane, 853,000 population Major cities: Savannakhet, 120,000; Pakse, 80,000; Luang Phrabang, 50,000; Thakhek, 35,000 Government Laos has a single-party communist government, in which the Lao Peoples Revolutionary Party (LPRP) is the only legal political party. An eleven-member Politburo and a 61-member Central Committee make all laws and policies for the country. Since 1992, these policies have been rubber-stamped by an elected National Assembly, now boasting 132 members, all belonging to the LPRP. The head of state in Laos is the General Secretary and President, Choummaly Sayasone. Prime Minister Thongsing Thammavong is the head of government. Population The Republic of Laos has approximately 6.5 million citizens, who are often divided according to altitude into lowland, Midland, and upland Laotians. The largest ethnic group is the Lao, who live mainly in the lowlands and makeup approximately 60% of the population. Other important groups include the Khmou, at 11%; the Hmong, at 8%; and more than 100 smaller ethnic groups that total about 20% of the population and comprise the so-called highland or mountain tribes. Ethnic Vietnamese also make up two percent. Languages Lao is the official language of Laos. It is a tonal language from the Tai language group that also includes Thai and the Shan language of Burma. Other local languages include Khmu, Hmong, Vietnamese and over 100 more. Major foreign languages in use are French, the colonial language, and English. Religion The predominant religion in Laos is Theravada Buddhism, which accounts for 67% of the population. About 30% also practice animism, in some cases alongside Buddhism. There are small populations of Christians (1.5%), Bahai and Muslims. Officially, of course, communist Laos is an atheistic state. Geography Laos has a total area of 236,800 square kilometers (91,429 square miles). It is the only land-locked country in Southeast Asia. Laos borders on Thailand to the southwest, Myanmar (Burma) and China to the northwest, Cambodia to the south, and Vietnam to the east. The modern western border is marked by the Mekong River, the regions major arterial river. There are two major plains in Laos, the Plain of Jars and the Plain of Vientiane. Otherwise, the country is mountainous, with only about four percent being arable land. The highest point in Laos is Phou Bia, at 2,819 meters (9,249 feet). The lowest point is the Mekong River at 70 meters (230 feet). Climate The climate of Laos is tropical and monsoonal. It has a rainy season from May to November, and a dry season from November to April. During the rains, an average of 1714 mm (67.5 inches) of precipitation falls. The average temperature is 26.5 °C (80 °F). Average temperatures over the year range from 34 °C (93 °F) in April to 17 °C (63 °F) in January. Economy Although the economy of Laos has grown at a healthy six to seven percent annually almost every year since 1986  when the communist government loosened central economic control and allowed private enterprise. Nonetheless, more than 75% of the workforce is employed in agriculture, despite the fact that only 4% of the land is arable. While the unemployment rate is only 2.5%, approximately 26% of the population live below the poverty line. Laoss primary export items are raw materials rather than manufactured goods: wood, coffee, tin, copper, and gold. The currency of Laos is the kip. As of July 2012, the exchange rate was $1 US 7,979 kip. History of Laos The early history of Laos is not well-recorded. Archaeological evidence suggests that humans inhabited what is now Laos at least 46,000 years ago, and that complex agricultural society existed there by about 4,000 BCE. Around 1,500 BCE, bronze-producing cultures developed, with complicated funeral customs including the use of burial jars such as those on the Plain of Jars. By 700 BCE, people in what is now Laos were manufacturing iron tools  and had cultural and trade contacts with the Chinese and Indians. In the fourth to eighth centuries CE, people on the banks of the Mekong River organized themselves into Muang, walled cities or petty kingdoms. The Muang were ruled by leaders who paid tribute to more powerful states around them. Populations included the Mon people of the Dvaravati kingdom and proto-Khmer peoples, as well as forebears of the mountain tribes. During this period, animism and Hinduism slowly mixed or gave way to Theravada Buddhism. The 1200s CE saw the arrival of ethnic Tai people, who developed small tribal states centered on semi-divine kings. In 1354, the kingdom of Lan Xang united the area that is now Laos, ruling until 1707, when the kingdom split into three. The successor states were Luang Prabang, Vientiane, and Champasak, all of which were tributaries of Siam. Vientiane also paid tribute to Vietnam.   In 1763, the Burmese invaded Laos, also conquering Ayutthaya (in Siam). A Siamese army under Taksin routed the Burmese in 1778, placing what is now Laos under more direct Siamese control. However, Annam (Vietnam) took power over Laos in 1795, holding it as a vassal until 1828. Laoss two powerful neighbors ended up fighting the Siamese-Vietnamese War of 1831-34 over control of the country. By 1850, the local rulers in Laos had to pay tribute to Siam, China, and Vietnam, although Siam exerted the most influence.   This complicated web of tributary relationships did not suit the French, who were accustomed to the European Westphalian system of nation-states with fixed borders. Having already seized control of Vietnam, the French next wanted to take Siam. As a preliminary step, they used Laoss tributary status with Vietnam as a pretext to seize Laos in 1890, with the intent of continuing on to Bangkok. However, the British wanted to preserve Siam as a buffer between French Indochina (Vietnam, Cambodia, and Laos) and the British colony of Burma (Myanmar).  Siam remained independent, while Laos fell under French imperialism. The French Protectorate of Laos lasted from its formal establishment in 1893 to 1950, when it was granted independence in name but not in fact by France. True independence came in 1954  when France withdrew after its humiliating defeat by the Vietnamese at Dien Bien Phu. Throughout the colonial era, France more or less neglected Laos, focusing on the more accessible colonies of Vietnam and Cambodia instead. At the Geneva Conference of 1954, the representatives of the Laotian government and of Laoss communist army, the Pathet Lao, acted more as observers than participants. As a sort of afterthought, Laos has designated a neutral country with a multi-party coalition government including Pathet Lao members. The Pathet Lao was supposed to disband as a military organization, but it refused to do so.  Just as troubling, the United States refused to ratify the Geneva Convention, afraid that communist governments in Southeast Asia would prove to correct the Domino Theory of spreading communism. Between independence and 1975, Laos was embroiled in a civil war that overlapped with the Vietnam War (American War). The famous Ho Chi Minh Trail, a vital supply line for the North Vietnamese, ran through Laos.  As the US war effort in Vietnam faltered and failed, the Pathet Lao gained an advantage over its non-communist foes in Laos. It gained control of the entire country in August  1975. Since then, Laos has been a communist nation with close ties to neighboring Vietnam and, to a lesser degree, China.

Dicussion on movie Essay Example | Topics and Well Written Essays - 250 words

Dicussion on movie - Essay Example In this film, ultimate gender performance is apparent in the way each manages realize their respective motives whereby Toby becomes a distinguished porn actor and Bree waitress in a place where there earlier her role encompassed washing dishes. Both key character deem they represent the opposite of what they are based on gender. Toby while indulging oneself into the acts of gay appears to be the recipient who through his charm arouses those of the same orientation. This is also evident with Bree who through her conduct all males whom she encounters end up exhibiting interests in without suspecting anything except that kid in the hotel. The latter among all other scenes is the sole incident, which I can concretely contend Bree utterly failed but all others she managed to masquerade as a woman. Conversely, Toby is successful all through and no incident where he seems to contradict who he is evident in the easily prostates to supplement their budget and lie proceeds were from selling drugs. In the film, the essence of nudity encompasses unveiling controversial aspects used to develop varied scenes constituting the entire movie as well as satiating audiences’ curiosity. For instance, Toby through nudity manages to know exactly Bree’s condition, which from the onset of the film viewers could only hear through discussion. In addition, nudity serves the role of advancing plots such that the film continues to progress, which is evident with the case of Toby having known who exactly Bree is an incident of rift between them develops until reconciliation in the end of the film. The film though its scenes might seem different from that of â€Å"The Hitch-Hiker (1953)† there earlier I watched, their general basis encompasses how the involved and key characters manage to scrutinize the reality of each other . In both films, there are hitchhikers

Company Law and Virtue Ethics Essay Example | Topics and Well Written Essays - 3000 words

Company Law and Virtue Ethics - Essay Example A promoter main duty is to offer sufficient funding or capital for the company and to ensure that all the formalities required by the statute of incorporation are met. The promoters have a fiduciary duty to the company and its shareholders. The promoters cannot use secret corporate information for their personal gain or advantage. Becky and Asif can sue Candy to reclaim the gift of Rex 2010 for breach of fiduciary duties. Promoters normally owe fiduciary duties to the company that they are forming. They should thus disclose any profit they are making from the promotion either to the company shareholders or to an independent board. The company may sue a promoter for disgorgement of the profit and for rescission in case there is a breach of duty. Becky and Asif can also replace Candy as a shareholder because the gift of Rex 2010 created a conflict of interest between Candy and the company. When shareholders have a conflict with the decision taken by one of the employees, he or she can be changed or replaced in accordance with its articles or the pertinent law provisions. Furthermore, a company enjoys an independent existence and is used by shareholders to achieve the shareholder's economic purposes. The company can thus be used as a means of replacing or seeking compensation from Candy because she created a risk of loss of compensation for the company. The gift was a business courtesy- it was a gift from a client. Before accepting the gift, Candy should have informed the other partners and not kept the gift for personal use, instead, she created a conflict of interest by having a business relationship with Yienshiu. The most imperative character of Candy’s job was not to acquire a secret gain at the expense of the company. Candy-a promoter- had a legal obligation not to make secret proceeds from promoting the company without the consent of the other promoters (Tengku Abdullah v Mohd Latiff bin Shah Mohd,[1996] 2 MLJ 265). She also had the legal duty of dis closing to the Company about the gift by Yienshiu. She was not transparent in her dealings with the other shareholders and thus did not remain true to her fiduciary duties (Fairview Schools Sdn. Bhd v Indrani a/p Rajaratnam (No1)[1998] 1 MLJ 110). The rights of the two shareholders-Becky & Asif- were harmed by an act done to the company, it is to the company that they should look to institute appropriate action because though the company and shareholders suffered the same wrong, it is only the two shareholders right that was infringed. Candy was seen by Becky and Asif as a fiduciary of the company because her relationship with the other shareholders was supposed to be one of confidence and trust. Candy owed legal and ethical duties to the company as well as to Becky & Asif which she did not honor. She did not exercise due care while carrying out her duty and did not subordinate her personal interests to the organization of the company. Candy abused her position of reliance at the co mpany in spite of the fact that Becky & Asif expected her to devote her full working efforts and time to the interests of the company and to stay away from any doings that would conflict or distract the company interests.